Liu, J. J., Huang, T. S., Cheng, W. F., and Lu, F. J. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. International Journal of Pharmacology 2010;6(2):81-88. 1997;11(3):125-131. Ann Intern Med 2012;156:894-5. At this time there is not enough scientific information to determine an appropriate range of doses for Baikal skullcap. Guo, H. X., Liu, D. H., Ma, Y., Liu, J. F., Wang, Y., Du, Z. Y., Wang, X., Shen, J. K., and Peng, H. L. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Liu, W., Mu, R., Nie, F. F., Yang, Y., Wang, J., Dai, Q. S., Lu, N., Qi, Q., Rong, J. J., Hu, R., Wang, X. T., You, Q. D., and Guo, Q. L. MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells. Baikal skullcap (scientific name Scutellaria baicalensis) is a plant. View abstract. Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. Planta Med 2000;66:91-3. Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. NIH National Cancer Institute. In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website. View abstract. 2003;34(3):504-506. Toxicology 5-2-2009;259(1-2):10-17. View abstract. 2011;10(2):184-191. View abstract. View abstract. However, both S. baicalensis root and its main flavonoid baicalin appear to have dose-dependent pro- and anti-angiogenic effects . In combination with other herbs, Baikal skullcap is used to treat attention deficit-hyperactivity disorder (ADHD), prostate cancer, a lung condition called bronchiolitis, arthritis, and hemorrhoids. Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. CNS.Neurol.Disord Drug Targets. This information may not fit your specific health circumstances. December 19, 2017. Lai, M. Y., Hsiu, S. L., Chen, C. C., Hou, Y. C., and Chao, P. D. Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. View abstract. How It Works Purported Uses and Benefits Do Not Take If Side Effects Special Point Back to top For Healthcare Professionals Scientific Name Clinical Summary Purported Uses and Benefits Mechanism of Action Contraindications Adverse Reactions References Back to top # A B View abstract. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. View abstract. The total content of these 6 main flavonoids account ed for 68.5% of the extract . Phytother Res 2000;14:210-2. View abstract. View abstract. Polysaccharides in S. barbata demonstrate antioxidant and free radical-scavenging activity(15). Hou, Y. C., Lin, S. P., Tsai, S. Y., Ko, M. H., Chang, Y. C., and Chao, P. D. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. Click Here. Sasaki, K., Taura, F., Shoyama, Y., and Morimoto, S. Molecular characterization of a novel beta-glucuronidase from Scutellaria baicalensis georgi. View abstract. Studies in humans are quite limited. Hu, Z., Yang, X., Ho, P. C., Chan, S. Y., Heng, P. W., Chan, E., Duan, W., Koh, H. L., and Zhou, S. Herb-drug interactions: a literature review. Wong, K. S. and Tsang, W. K. In vitro antifungal activity of the aqueous extract of Scutellaria baicalensis Georgi root against Candida albicans. Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. Taking Baikal skullcap with medications used to treat high blood pressure might cause blood pressure levels to go to low. 2007;56(6):280-283. Cancer Chemother.Pharmacol 2011;67(5):1063-1072. Keep in mind that natural products are not always necessarily safe and dosages can be important. The ethyl acetate (EtOAc) extract showed high ROS scavenging ability, and four compounds were subsequently isolated and purified from this extract: baicalin, baicalein, wogonin, and oroxylin A. Baicalein in rat lung mitochondria the most significant LHP-induced LPO inhibition was shown and extracted with EtOAc that contained the Chang, W. H., Chen, C. H., and Lu, F. J. Opposite expression of securin and gamma-H2AX regulates baicalein-induced cancer cell death. Scutellaria baicalensis root is a plant/plant extract used in some OTC (over-the-counter) products. 9-7-2009;125(2):286-290. Fu, J., Cao, H., Wang, N., Zheng, X., Lu, Y., Liu, X., Yang, D., Li, B., Zheng, J., and Zhou, H. An anti-sepsis monomer, 2',5,6',7-tetrahydroxyflavanonol (THF), identified from Scutellaria baicalensis Georgi neutralizes lipopolysaccharide in vitro and in vivo. Baicalein: an in vitro antigenotoxic compound from Scutellaria baicalensis. View abstract. Immunopharmacology 2000;49:295-306. Planta Med 1998;64:571-2. Zhou, X. Q., Liang, H., Lu, X. H., Cai, S. Q., Wang, B., and Zhao, Y. Y. Case Reports Heptal 2016;2016:4356749. Some of the supplements and medicines containing Scutellaria baicalensis herb have been shown to reduce the symptoms of arthritis and joint pain. View abstract. 1989;35(3):331-335. With cancer, where you get treated first matters. Baicalin from the extract of Scutellaria baicalensis affects the innate immunity and apoptosis in leukocytes of children with acute lymphocytic leukemia. Am J Chin Med 2008;36(3):517-540. Cancer Res 7-15-2003;63(14):4037-4043. Please do not use SMS English, Short Text and Words like hi, hello. This is especially relevant to macrophages and immune cells. Ong, E. S., Len, S. M., and Lee, A. C. Differential protein expression of the inhibitory effects of a standardized extract from Scutellariae radix in liver cancer cell lines using liquid chromatography and tandem mass spectrometry. 2008;31(5):707-710. View abstract. Ciesielska, E., Wolszczak, M., Gulanowski, B., Szulawska, A., Kochman, A., and Metodiewa, D. In vitro antileukemic, antioxidant and prooxidant activities of Antoksyd S (C/E/XXI): a comparison with baicalin and baicalein. Planta Med 2000;66:91-3. Side effects are few and may include drowsiness. Ceska.Slov.Farm. Therapeutic effect of Scutellaria baicalensis on L-thyroxine-induced hyperthyroidism rats. View abstract. Huang KC. Takahashi, H., Chen, M. C., Pham, H., Angst, E., King, J. C., Park, J., Brovman, E. Y., Ishiguro, H., Harris, D. M., Reber, H. A., Hines, O. J., Gukovskaya, A. S., Go, V. L., and Eibl, G. Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. To avoid any unwanted skin irritation you should consult with a doctor, dermatologist or trained professional before applying the ingredient onto the skin. Cancer Lett. Hao, H., Aixia, Y., Dan, L., Lei, F., Nancai, Y., and Wen, S. Baicalin suppresses expression of Chlamydia protease-like activity factor in Hep-2 cells infected by Chlamydia trachomatis. Diabetes: Baikal skullcap can affect blood sugar levels in people with diabetes. Cancer Lett. There is, for example, an algae extract trade-named Lanablue that comes from blue-green algae (green algae is rare, less than 1% of the total macroalgae in the world) and is claimed to have retinoid like effects (i.e. WebThe root of Scutellaria baicalensis is used as medicine. 2019;49(4):544-546. 5-24-2006;105(3):346-351. View abstract. Talk with your healthcare provider before using this product if you are taking lithium. Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Get medical attention if irritation develops and persists. A traditional 2021 Jun 28;274:114052. Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., and Zhang, D. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. View abstract. The dose of your diabetes medication might need to be changed. Liu, C. Z. and Chen, D. W. [Sanhuang tablets research]. View abstract. First-aid measures Inhalation Move to fresh air. J Ethnopharmacol. Shang, Y. From diagnosis to treatment, our experts provide the care and support you need, when you need it. Toxicol.Appl.Pharmacol 8-1-2011;254(3):221-228. Porterfield, H. UsToo PC-SPES surveys: review of studies and update of previous survey results. Chung Hsi I Chieh Ho Tsa Chih 1990;10:278-9, 260. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. This could change the effects and side effects of these medications. Eur J Haematol. View abstract. View abstract. Before taking Baikal skullcap, talk to your healthcare provider if you take any medications that are changed by the liver. View abstract. View abstract. Interactions Do not use Chinese skullcap with alcohol or the following [Application of XRF to the analysis of Scutellaria baicalensis with space mutagenesis]. View abstract. View abstract. Zhang, K., Lu, J., Mori, T., Smith-Powell, L., Synold, T. W., Chen, S., and Wen, W. Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha} pathway. Linnebur, S. A., Rapacchietta, O. C., and Vejar, M. Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. View abstract. View abstract. Kimura, Y., Matsushita, N., Yokoi-Hayashi, K., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis Radix on adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. This study reports three major findings: (1) S. baicalensis has a potent inhibitory effect Waisundara, V. Y., Hsu, A., Huang, D., and Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. Taking Baikal skullcap along with sedative medications might cause too much sleepiness. No matter new buyer or old purchaser, We believe in long expression and trusted relationship for Scutellaria Baicalensis Root, Nootropics Modafinil, Herbal Extract Oil, Maca Extract Liquid, Hawthorn Extract Vs Hawthorn Berry. Zhang, X. W., Li, W. F., Li, W. W., Ren, K. H., Fan, C. M., Chen, Y. Y., and Shen, Y. L. Protective effects of the aqueous extract of Scutellaria baicalensis against acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells. View abstract. Therefore, one should not take the herb on their own Rather; they should ask a doctor and go with a suitable preference for treating cancer. The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. View abstract. View abstract. Accessed Sept 30, 2016. Involvement of p53 in oroxylin A-induced apoptosis in cancer cells. Song, S. H. and Wang, Z. Some medications are changed and broken down by the liver. Chem Pharm Bull (Tokyo) 1992;40(2):531-533. WebBaicalin is a great herbal supplement for health benefits. View abstract. View abstract. View abstract. With cancer, where you get treated first matters. Cancer Lett. These include the Chinese Skullcap, Huang Qin, Scutellaria baicalensis (the scientific name), and the Hooded Willow Herb. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. RxList does not provide medical advice, diagnosis or treatment. View abstract. Adv Ther 2010;27:731-42. CAS #:94279-99-9 | EC #:304-845-9. Cancer Lett. Planta Med 2000;66:70-1. Pneumonitis induced by ou-gon (scullcap). Contact Dermatitis. Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS. An herbal supplement containing S. baicalensis reduced symptoms of osteoarthritis(22). View abstract. Journal of China Pharmacy 2010;21. Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study. [Study of Scutellaria baicalensis and Baicalin against antimicrobial susceptibility of Helicobacter pylori strains in vitro]. Wu, J. Y., Chung, K. T., Liu, Y. W., Lu, F. J., Tsai, R. S., Chen, C. H., and Chen, C. H. Synthesis and biological evaluation of novel C(6) modified baicalein derivatives as antioxidative agents. View abstract. 5. B., Blach-Olszewska, Z., and Aliev, G. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? Cancer Sci 2011;102(4):870-876. Leung, H. W., Yang, W. H., Lai, M. Y., Lin, C. J., and Lee, H. Z. Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. View abstract. 2006;63(2):95-96. Chemicals in skullcap might cause sleepiness. Sichuan.Da.Xue.Xue.Bao.Yi.Xue.Ban. View abstract. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. Some cancer cell lines undergo cell death when exposed to extracts of this herb, but some compounds in this herb may actually have opposite effects. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Gao, J., Morgan, W. A., Sanchez-Medina, A., and Corcoran, O. Some medications are changed and broken down by the liver. Baikal skullcap might slow blood clotting. Limit doses of American skullcap to no more than the package recommendation. Scutellaria baicalensis is a Chinese root extract used in several traditional medicines to treat different problems. View abstract. Food Chem Toxicol. Armstrong, T. S. and Gilbert, M. R. Use of complementary and alternative medical therapy by patients with primary brain tumors. Planta Med 2000;66:70-1. Blaszczyk T, Krzyzanowska J, Lamer-Zarawska E. Screening for antimycotic properties of 56 traditional Chinese drugs. Scutellaria baicalensis Georgi extracts inhibit RANKL-induced osteoclast differentiation. Beijing Da.Xue.Xue.Bao. Bonham, M., Posakony, J., Coleman, I., Montgomery, B., Simon, J., and Nelson, P. S. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Further studies are needed. Therefore, if you are a diabetic patient, you should stay away from such herbs. Chan, F. L., Choi, H. L., Chen, Z. Y., Chan, P. S., and Huang, Y. 2013;140:22-30. Food Chem . Baikal skullcap might have some of the same effects as estrogen. 5-17-2011;135(2):359-368. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. 2000;4(3):289-291. African Journal of Biotechnology 2011;10(26):5182-5192. CNS.Neurol.Disord Drug Targets. Am J Chin Med 2006;34(2):245-261. View abstract. Enomoto, R., Koshiba, C., Suzuki, C., and Lee, E. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. Ye, F., Xui, L., Yi, J., Zhang, W., and Zhang, D. Y. Anticancer activity of Scutellaria baicalensis and its potential mechanism. Udintsev, S. N., Razina, T. G., and Iaremenko, K. V. [The antitumor effect of Baikal skullcap]. Int J Mol Med 2004;14(4):627-632. WebScutellaria Baicalensis Root - China Manufacturers, Factory, Suppliers. View abstract. Vopr.Onkol. Taking Baikal skullcap along with estrogen pills might decrease the effects of estrogen pills. In some cases, this might change the effects and side effects of a medication. Chen C, Mireles RJ, Campbell SD, et al. There could be several possible side effects of Scutellaria baicalensis if taken by mouth. Pharmacol Biochem Behav 2009;92(4):642-648. J Nat Prod 1997;60(6):598-601. Drugs 2005;65(9):1239-1282. Huang, R. L., Chen, C. C., Huang, H. L., Chang, C. G., Chen, C. F., Chang, C., and Hsieh, M. T. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. View abstract. root of Scutellaria baicalensis Georgi. 2009;86(2):79-84. Vitamin D Deficiency: How Much Vitamin D Is Enough? Yuan Y., Liu Y.J, Luo Y.J, and et al. A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments Afr J Tradit Complement Altern Med. OTHER NAME(S): Baicalein, Baikal Scullcap, Baikal Skullcap Root. Some constituents may also have neuroprotective (4) (5) , anticonvulsant (6) , and anti-inflammatory (17) effects. Ann N Y Acad Sci 2007;1095:521-526. Yotsumoto, H., Yanagita, T., Yamamoto, K., Ogawa, Y., Cha, J. Y., and Mori, Y. Inhibitory effects of oren-gedoku-to and its components on cholesteryl ester synthesis in cultured human hepatocyte HepG2 cells: evidence from the cultured HepG2 cells and in vitro assay of ACAT. Z., Qin, B. W., Cheng, J. J., and Miao, H. Effect of Scutellaria flavonoids on KCN-induced damages in rat pheochromocytoma PC12 cells. Toxicology 3-4-2009;257(1-2):80-85. View abstract. Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. Macrophages are specifically involved in the initiation, maintenance, and resolution of inflammation. Krakauer, T., Li, B. Q., and Young, H. A. View abstract. View abstract. Diabetes medications are also used to lower blood sugar. People with diabetes should not take Chinese skullcap without consulting a doctor as it may lower blood sugar, Int J Antimicrob.Agents 2009;34(3):284-285. Yoon, S. B., Lee, Y. J., Park, S. K., Kim, H. C., Bae, H., Kim, H. M., Ko, S. G., Choi, H. Y., Oh, M. S., and Park, W. Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. Chalasani N, Vuppalanchi R, Navarro V, et al. Chen, C. S., Chen, N. J., Lin, L. W., Hsieh, C. C., Chen, G. W., and Hsieh, M. T. Effects of Scutellariae Radix on gene expression in HEK 293 cells using cDNA microarray. Eur J Drug Metab Pharmacokinet. View abstract. Avoid skin and eye contact and breathing in dust. 7-28-2004;211(1):39-46. 1997;57(1):63-67. This herb is often used alone, whereas many times, it is used with other herbs in combination. Adam T, Bursztejn AC, Schmutz JL. In animal models, attenuation of asthma was attributed to reduced airway injury and restored mitochondrial function(19). But there isn't enough information to know if this is an important interaction. Some medications are moved in and out of cells by pumps. View abstract. 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