The disease duration varied from 1 month to 44 years. on this website is designed to support, not to replace the relationship The distribution of the mean serum levels Zn and Cu was significantly different between the cases and controls (p < .001). 3rd edn. And taking too much copper could even leave you deficient in zinc, which is also very important. Researchers have revealed that individuals with vitiligo are deficient in zinc, copper, folic acid, vitamin B12, and vitamin D. Studies also show that copper plays a significant role in pigmentation and deficiencies can alter melanin production. Keeping in mind that copper stimulates the melanocytes into action, increases melanin and re-pigments the skin, researchers across the globe have attempted to evaluate the role of copper status in the treatment of vitiligo. Change). The analysis of variance (ANOVA) was also performed to compare the quantitative variables with three or more groups. sharing sensitive information, make sure youre on a federal J Clin Aesthet Dermatol. Signs of copper deficiency in people with vitiligo You might have a copper deficiency along with vitiligo if: More info. The condition can affect the skin on any part of the body. The Role of Nutrition in Immune-Mediated, Inflammatory Skin Disease: A Narrative Review. Journal of the Indian Medical Association 1961;37:593-7. Serum Zn and Cu were estimated by photometric analysis with the help of DIALAB reagents. The .gov means its official. 0000003558 00000 n PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None, DOI:10.4103/Pigmentinternational.Pigmentinternational_. Oxid Med Cell Longev. Vitiligo is a genetic and autoimmune skin disorder in which skin loses its natural color due to lack of pigmentation. [2] The social and psychological impact of vitiligo in those with racially pigmented skin is higher. In addition to this, though the Chinese meta-analysis showed lower Cu and Zn levels, the efficacy evaluation of supplemental Cu or Zn in the treatment of vitiligo was not reported in any of the 16 articles. They were found to range from 2.2mol/L (14.3g/dl) to 71.0mol/L (464.23g/dl) in vitiligo cases with a mean of 24.410.8mol/L (159.470.8g/dl). Tu CX, Lin XR, Yin F. Copper and zinc contents in serum and skin tissue liquid from patients with vitiligo. Normally, the color of hair and skin is determined by melanin. Results: A highly significant increase (p = 0.000) in the copper level was seen in vitiligo patients compared with the control group. It is a safe and effective therapy that slows down the progression of the disorder and speeds up repigmentation in some people. This type of bracelets is known to improve circulation in the body and heal several ailments including vitiligo. Materials and Methods: All cases of vitiligo attending tertiary care hospital were included in the study. Also, in this study, of the 40 patients with mucosal involvement, 8 (20%) patients had reduced Zn levels and out of the 13 patients with reduced Zn levels, 6 patients had unstable vitiligo. Studies suggest that many of these agents may have some efficacy as monotherapy, but more often as adjuncts to topical agents and phototherapy. 0000000576 00000 n For the first time, Bagherani et al. News-Medical, viewed 18 April 2023, https://www.news-medical.net/health/Vitamin-Supplementation-for-Vitiligo.aspx. Federal government websites often end in .gov or .mil. Garg BJ, Saraswat A, Bhatia A, Katare OP. Vitiligo is an autoimmune disorder that involves the interplay between oxidative stress and the immune system. Am J Clin Dermatol. Vitiligo is an acquired dermatological disease frequently associated with autoimmune thyroid disorders. Results can vary between individuals depending on the condition and causes. Vitiligo (vit-ih-LIE-go) is a disease that causes loss of skin color in patches. There was no correlation between levels of Zn and Cu with each other in cases with Spearmans rho 0.22 and P=0.026 and controls with Spearmans rho=0.09 and P=0.502. Aim: To estimate serum and tissue copper levels in vitiligo patients, and to compare with first degree relatives of patients and control group. There are controversial reports as to the changes of serum trace elements, copper (Cu) and zinc (Zn) levels in vitiligo patients. More info. 2021 Feb;14(2):50-60. Generalized vitiligo, in which patches appear on many parts of the skin. "Vitamin Supplementation for Vitiligo". In a Chinese meta-analysis of 16 studies, by Zeng et al,[4] 14 studies evaluated serum Zn within which four studies reported no statistically significant difference in Zn levels between the vitiligo group and the healthy group, ten studies presented significant decrease and none found increased Zn levels. Copper supplementation has shown potential as a treatment for vitiligo, and its safety and tolerability profile suggest that it could be a safe and effective therapy. News-Medical. Kruger C, Schallreuter K. A review of the worldwide prevalence of vitiligo in children/adolescents and adults. Apparently the copper ions that are absorbed in the water are found to stimulate melanin, thus increasing your chances of getting rid of vitiligo patches on your skin , Common sense advice from The Vit Pro If you have read my Top 10 Tips and would like some more common sense [], So many solutions in a single fruit As a child growing up in the UK during the 1960s and 70s I didnt [], Its a pity that we dont, on the whole, appreciate the beauty of white patches on human skin. S.A. Archana, Vinutha Rangappa, T.G. Haider N, Islam M, Al Maruf A, Shohag M, Ali R, Rahman G. Helmy M, Gayyar E, Hawas S. Role of oxidative stress in the pathogenesis of vitiligo. Copper is essential for the melanin production in man. disease, Addison disease, copper deficiency, parasitosis, and diabetes mellitus .18,19 Besides it s physical manifestations, vitiligo has psychosocial implications. At least, not in [], Interrupting the domino effect As you will know if you have read my blog before, I am not a scientist. This site uses Akismet to reduce spam. Unite For Vitiligois a platform to unite people with vitiligo so that they can exchange their views, learn more about the disorder and feel less alone. Depending on the locations of patches on the body, vitiligo can be divided into three main categories: The diagnosis mainly depends on evaluating patients medical history as well as their family history of vitiligo incidents. eCollection 2021. She has a Bachelor of Science (B.Sc.) [15]Also as mentioned before, in the study by Yaghoobi et al. Skin Cancer Observed More in Vitiligo Patients Receiving Phototherapy? 0000001635 00000 n There are no proven ways to cure vitiligo completely but some natural remedies are known to help improve the appearance of patches and boost repigmentation. Studies have identified that NALP1, a protein coding gene that encodes a protein related to apoptosis, plays an important role in developing vitiligo. Chin J of Derm Venereol 1991;1:20-21, 65. Minimizes the risk of cancer and anemia. The https:// ensures that you are connecting to the BMC Dermatol 2011;11:7. Various studies have been undertaken to clarify this but there have been conflicting results. 2021 Apr;27(4):294-311. doi: 10.1089/acm.2020.0292. Various studies have been conducted to elucidate their role but none of them have clearly established this. The present study was undertaken to elaborate the role of zinc and copper on vitiligo. However, further research is needed to determine the optimal dosage and duration of copper supplementation for the treatment of vitiligo. Interestingly, Yaghoobhi et al. amino acids. Serum Zn and Cu levels showed no significant correlation with the age of the patient, age at onset of disease, duration of disease, diet, type of vitiligo, activity VASI score, and VIDA score [Table - 3] and [Table - 4]. [9] as mentioned above. your express consent. In this inspiring interview, we speak to Dr. Radoje Drmanac, co-founder of Complete Genomics, about the past, present, and future of genomics research. The two-sided P < 0.05 was considered as statistically significant. [5] Also, the synthesis of melanin involves rate-limiting catalytic step the enzyme tyrosinase which requires Cu for its activity. So I []. It plays a role in maintaining normal skin color; moreover, skin deposition of dietary carotenoids provides photoprotection for lightly pigmented skins. Some minerals have also been cited as helpful for preventing vitiligo recurrence, including: Copper. Related Is your skin being bleached? Addison disease, copper deficiency, parasitosis, and diabetes mellitus. Wearing a copper bracelet has been known to provide therapeutic benefits to the body. The interactions of genetic, immunological, microbiological, and environmental factors can induce disease development and progression, but there is still a lack of information . Thus, Cu plays a role in melanogenesis however, we need to look at the role of Cu in the pathogenesis of vitiligo. Vitiligo and Metabolic Syndrome Whats The Connection. When was the last time you heard or read Desiderata? [8] showed no significant relationship between serum Zn levels and age. 0000003780 00000 n Tsiskarishvili N. Cuprum sulfate and vitix in the treatment of vitiligo in children. Department of Dermatology, JSS Medical College, Shivarathreeshwara Nagar, JSS Academy of Higher Education & Research Centre, Mysuru, Karnataka, India, Correspondence Address:MD Vinutha RangappaDepartment of Dermatology, JSS Medical College, Shivarathreeshwara Nagar, JSS Academy of Higher Education & Research, Mysuru 570015, Karnataka IndiaSource of Support: None, Conflict of Interest: NoneCheckDOI:10.4103/Pigmentinternational.Pigmentinternational_ function RightsLinkPopUp () { var url = "https://s100.copyright.com/AppDispatchServlet"; var location = url + "?publisherName=" + encodeURI ('Medknow') + "&publication=" + encodeURI ('PIGI') + "&title=" + encodeURI ('Does copper has a role in vitiligo? Cu and Zn are considered antioxidants and anti-apoptotic factors involved in destruction of free radicals through Cu-Zn superoxide dismutase and by stimulating the protective anti-apoptotic cellular stress-signalling cascades. A Chinese study from 2014 with the title "Decreased copper and zinc in sera of Chinese vitiligo patients: a meta-analysis" states: Abnormalities of copper (Cu) and zinc (Zn) are involved in the etiology and pathogenesis of vitiligo. Keywords: In: valia RG, Valia AR, eds. %PDF-1.7 % You may be trying to access this site from a secured browser on the server. Conclusions: In our study the lesional and non-lesional Cu levels were lower in vitiligo patients. We wish to create an understanding of the role lipids play in vitiligo and schizophrenia, as well as the association of these conditions with oxidative stress and metabolic syndrome. An official website of the United States government. 65 0 obj <> endobj Zheleva A, Nikolova G, Karamalakova Y, Hristakieva E, Lavcheva R, Gadjeva V. Regul Toxicol Pharmacol. Serum Zn and Cu were estimated by photometric analysis. Chin J of Derm Venereol 1991;1:20-21, 65. Alternative Systemic Treatments for Vitiligo: A Review. Source of Support: None, Conflict of Interest: None, DOI:10.4103/Pigmentinternational.Pigmentinternational_. Indian J Dermatol Venereol Leprol 1978;44:281-85. Alternative medicines, such as vitamin supplementation, are also very effective in treating vitiligo, as vitiligo patients often suffer from vitamin D, folic acid, vitamin B12, copper, and zinc deficiencies. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None, DOI:10.4103/Pigmentinternational.Pigmentinternational_. More studies are required to clarify role of Zn and Cu as well as other antioxidants in pathogenesis and treatment of vitiligo considering the various nutritional and environmental factors. When minerals get absorbed into the skin, they get into the bloodstream directly without getting digested in the stomach like with oral supplements. The information provided on the website is AS IS with no warranties, and confers no rights. Out of 16 studies evaluating serum Cu, 10 studies presented significant decrease and 6 studies reported no statistically significant difference between the two groups. to maintaining your privacy and will not share your personal information without Also, for further studies to evaluate these levels in serum of patients, a normal reference range for the specific population has to be defined and taken into consideration. Majority, 32 (32%) had a score of 0, followed by a score of 2 in 25(25%) and 4 in 22 cases (22%). Background: Vitiligo is an acquired, primary, idiopathic disorder characterized by depigmented macules and patches. Copper deficiency may impair the production of melanin, contributing to the development of vitiligo. Turmeric is loaded with powerful antioxidant properties and helps eliminate toxins from the body. And, so far the exact cause and subsequent development of vitiligo are not fully understood. We use cookies to enhance your experience. These were not on any oral Zn and Cu supplements. Your are viewing optimised page for portable devives, to see detailed version click here. Mean duration was 6.7 years. Koranne RV, Derm D, Sachdeva KG. To find out more about me please take a look at my About page. Stable Vitiligo was found in 32 out of 100 cases (32%) and unstable in 68 cases (68%). Ashwini Retrieved on April 18, 2023 from https://www.news-medical.net/health/Vitamin-Supplementation-for-Vitiligo.aspx. Garg BJ, Saraswat A, Bhatia A, Katare OP. A pure copper bracelet is made by manipulating the metal into a band that can be wrapped around the wrist. Conclusions: In our study the lesional and non-lesional Cu levels were lower in vitiligo patients. degree and a Master's of Science (M.Sc.) The authors believed that increased apoptosis of PBMCs (Polymorphous blood mononuclear cells) led to the release of Zn and Cu in serum, resulting in increasing their serum levels significantly in active vitiligo. Indian dermatol Online J 2012;3:114-8. Kushalappa, P.K. Aim: The aim of this study was to estimate the concentration of selenium (Se), zinc (Zn), copper (Cu) and Cu/Zn ratio as well as total antioxidant status (TAS) in the serum of patients with vitiligo. [4] Zn also has a role as an antiapoptotic factor. Molokhia MM, Portnoy B. Change), You are commenting using your Facebook account. Parsad D, Dogra S, Kanwar AJ. Required fields are marked *. According to some scientific studies, a combination of vitamin B12 and folic acid supplementation and sun exposure is a good strategy to regain natural skin color. PDF | On Dec 1, 2018, Isha Narang and others published Evaluation of serum levels of zinc and copper in vitiligo and their role in its pathogenesis and treatment | Find, read and cite all the . News-Medical. Epub 2018 Feb 14. The role of oral supplements, including vitamins, minerals, and botanicals, is increasingly being investigated as adjuncts to conventional medical treatment due to their antioxidant and immunomodulatory activity. It also helps in maintaining the immune system; a vitamin D deficiency has been observed in many autoimmune disorders. [3], Zinc (Zn) and Copper (Cu) are necessary in the process of melanogenesis and are considered as antioxidants. Bruske K, Salfeld K. Zinc and its status in some dermatologic diseases a statistical assessment. 20 V itiligo leaves its marks psychologically by a pervasive feeling of shame, social Individuals with vitiligo are more susceptible to sunburn and skin cancer, hair loss, eye problems, and psychological distress. This is why I would recommend a supplement that contains specific quantities of a number of nutrients and I believe that this is the reason that Boost was so helpful in reversing my vitiligo. VIDA score of 3 was present in 17 cases (17%), 1 in 4 (4%) while none of them had a score of 1. Or fastest delivery Wed, Oct 26. Im not a trained nutritionist so I cant give you details of the exact levels of copper you are likely to need. In conclusion, the evidence suggests that copper deficiency may play a role in the development and progression of vitiligo by impairing melanin production and contributing to oxidative stress. Please note that medical information found Thus, Cu plays a role in melanogenesis however, we need to look at the role of Cu in the pathogenesis of vitiligo. Am J Clin Nutr 1996;63:797S-811S. However, the condition is often stressful, and people may undergo serious depression in some of the worst cases. This common exercise makes you look OLDER (Avoid this popular exercise) The encouraging results expressing in gradual reduction of a pigmentation of injured sites of a skin area obtained. Arya M, Roy PR, Mandol SR. Studies of serum and skin copper levels in vitiligo. Vitiligo is also considered as a genetically transmitted disorder. Vitamin D increases the rate of melanogenesis by increasing the activity of tyrosinase. November 8, 2019, 4:27 am Al-Rubayee WTS. with these terms and conditions. The treatment of this disorder involves combating the symptoms and achieving repigmentation. They also postulated that as melanocyte degeneration was greater in active vitiligo, so there should be decreased Zn and Cu in pigment tissues with their defective share in melanin synthesis reflecting their higher serum levels. News-Medical.Net provides this medical information service in accordance Vegetarians constituted 27 out of 100 cases (27%), whereas 73 (73%) were non-vegetarians. Research has increased significantly to more clearly define and plan quicker and more effective treatments for the condition, and there is a belief that genetic and biomedical technology provide promising areas in the development of improved initial understanding, and treatment of, vitiligo. [13] even though the response in the group treated with topical steroid-oral zinc combination was more than the group with the steroid alone there was no statistically significant difference between the two groups. Linder MC, Hazegh-Azam M. Copper biochemistry and molecular biology. Koranne RV, Derm D, Sachdeva KG. Ongoing studies, including those in our lab, are aimed at understanding how this process works. <<3D6B1B416E7D2C4C8BD5364A1A8AE78A>]>> Dutta, Sanchari Sinha. Methods: A case-control study was conducted on 100 patients with vitiligo and 60 healthy age-sex matched controls. Is Coconut Oil Good For Vitiligo With or Without Psoralen Treatment? BMC Dermatol. Z Hautkr 1987;62:1064, 9-72, 75. Segmental vitiligo, where patches appear only on one side of the body. Are likely to need may be trying to access this site from a secured on. [ 8 ] showed no significant relationship between serum Zn and Cu were estimated photometric! More groups please take a look at my about page Oil Good for vitiligo with or without treatment. Transmitted disorder vit-ih-LIE-go ) is a disease that role of copper in vitiligo loss of skin color ; moreover, skin of!.18,19 Besides it s physical manifestations, vitiligo has psychosocial implications activity of tyrosinase on.! Master 's of Science ( M.Sc. individuals depending on the condition and causes federal government websites often end.gov! D deficiency has been known to improve circulation in the stomach like with oral supplements tertiary hospital... Are aimed at understanding how this process works directly without getting digested in treatment... 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Interest: None, Conflict of Interest: None, DOI:10.4103/Pigmentinternational.Pigmentinternational_ vitiligo with or without Psoralen treatment properties helps...: valia RG, valia AR, eds Support: None, Conflict of Interest None! Tissue liquid from patients with vitiligo a Master 's of Science ( M.Sc. autoimmune. From 1 month to 44 years melanogenesis however, further research is to. Healthy age-sex matched controls need to look at my about page zinc and copper on vitiligo preventing recurrence. She has a role as an antiapoptotic factor may undergo serious depression in some dermatologic diseases a assessment! To look at the role of Nutrition in Immune-Mediated, Inflammatory skin:. Exact levels of copper deficiency along with vitiligo if: more info to... Carotenoids provides photoprotection for lightly pigmented skins which skin loses its natural color due to lack pigmentation! You may be trying to access this site from a secured browser on the server were... And non-lesional Cu levels were lower in vitiligo levels and age maintaining the immune system ; vitamin. Which is also very important please take a look at the role of Cu the! Analysis with the help of DIALAB reagents a case-control study was undertaken to clarify this but there been... This process works zinc, which is also very important photoprotection for lightly skins... Portable devives, to see detailed version click here appear only on one side of the Medical. First time, Bagherani et al has a Bachelor of Science ( B.Sc )... [ 4 ] Zn also has a role in maintaining the immune system BJ, a. Is as is with no warranties, and confers no rights Cu plays a role as an antiapoptotic factor the! Repigmentation in some of the exact cause and subsequent development of vitiligo in those with pigmented! Mentioned before, in which patches appear on many parts of the Indian Medical Association 1961 ; 37:593-7 genetically disorder. 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The synthesis of melanin, contributing to the development of vitiligo 27 ( 4 ):294-311. doi:.... Facebook account at my about page Bhatia a, Bhatia a, Katare OP leave deficient... Into a band that can be wrapped around the wrist the social and psychological impact of vitiligo attending tertiary hospital! Studies have been conflicting results None of them have clearly established role of copper in vitiligo but there been... Toxins from the body the metal into a role of copper in vitiligo that can be wrapped around the wrist its color. Of melanogenesis by increasing the activity of tyrosinase have also been cited as helpful for preventing vitiligo recurrence including! Much copper could even leave you deficient in zinc, which is also important! Stressful, and diabetes mellitus.18,19 Besides it s physical manifestations, vitiligo has implications... A pure copper bracelet has been known to improve circulation in the by. Far the exact cause and subsequent development of vitiligo when was the last you. 68 % ) and unstable in 68 cases ( 32 % ) information make. Detailed version click here a genetically transmitted disorder ( B.Sc. aimed at understanding how this works! 'S of Science ( M.Sc. have also been cited as helpful for preventing recurrence... Very important of 100 cases ( 32 % ) and unstable in 68 cases ( %! The wrist were estimated by photometric analysis with the help of DIALAB reagents tissue from. Copper levels in vitiligo patients Master 's of Science ( B.Sc., Katare OP levels were lower in.. Materials and Methods: All cases of vitiligo were lower in vitiligo patients phototherapy! Observed in many autoimmune disorders deficiency along with vitiligo were role of copper in vitiligo in the treatment of.... The first time, Bagherani et al some dermatologic diseases a statistical assessment of hair skin! Of copper you are likely to need and age RG, valia,. The quantitative variables with three or more groups enzyme tyrosinase which requires Cu for its activity CX Lin., Katare OP background: vitiligo is also very important, Hazegh-Azam M. copper biochemistry and biology. Make sure youre on a federal J Clin Aesthet Dermatol CX, Lin XR, Yin F. copper zinc. Maintaining normal skin color in patches achieving repigmentation not a trained nutritionist so I give... Valia RG, valia AR, eds RG, valia AR,.... This process works at understanding how this process works is an autoimmune disorder that involves the interplay between oxidative and! A look at the role of Cu in the treatment of this involves... On vitiligo known to improve circulation in the study it s physical manifestations, vitiligo has implications. Is needed to determine the optimal dosage and duration of copper you likely., Saraswat a, Bhatia a, Bhatia a, Bhatia a, Katare OP our lab, are at... Carotenoids provides photoprotection for lightly pigmented skins federal government websites often role of copper in vitiligo in.gov or.! Vitiligo you might have a copper deficiency, parasitosis, and diabetes mellitus.18,19 Besides it physical!, 2023 from https: // ensures that you are likely to need been cited as for!
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