Noubar Afeyan, co-founder of Moderna Inc. and CEO of Flagship Pioneering Inc., discusses the remaining challenges in the Covid-19 vaccination efforts and the progress in creating shots for children. He is also the founder of a company called PerSeptive Biosystems. The park symbolizes our diversity. I cover the world's richest people and how they made their billions. Noubar Afeyan has cofounded more than 35 successful life sciences and technology start-ups, but likely none more impactful than Moderna, Inc., which last year came up with the first mRNA-1273 COVID-19 vaccine, now protecting millions around the world from the pandemic virus. He became chief business officer of Applera, the successor company to Perkin-Elmers life sciences business, but was soon thinking about his next move. Without the pandemic, Afeyan says, putting his hand on his head, we probably would not be as hellbent on doing it as we are now., Every one of our companies is born to aspire to what Moderna has done. [32][15][2], a founding angel of Foundation for Armenian Science and Technology (FAST). ahin is the CEO and cofounder of BioNTech, which he started alongside his wife and chief medical officer zlem Treci. As the firms researchers explore ideas, theyll change their approachor even what theyre working onwith little regard for how the outside world might view such seeming flip-flops. Afeyan is leveraging that success to raise boatloads of new cash. At the same time, one high-profile investor in Cambridge, Massachusetts-based vaccine maker Modernalife sciences VC outfit Flagship Pioneering, led by Moderna cofounder and chairman Noubar Afeyancashed in on the firms soaring stock price, selling more than $1.5 billion in shares since the World Health Organization declared a pandemic on March 11, 2020. Noubar was born in Beirut to Armenian parents in 1962, did his undergraduate work at McGill University in Montreal, and completed his Ph.D. in biochemical engineering at MIT in 1987. Franklin was only 37 when she died of ovarian cancer; the many X-rays she absorbed in her lab may have been a factor. Prior to founding Flagship Pioneering, Noubar was the founder and CEO of PerSeptive Biosystems, a leader in bio-instrumentation that grew to $100 million in annual revenues. I had to try to explain it. [There were about 3 million Jews in 1847, out of a world population of 1.2 billion or 0.25%]. Noubar Afeyan is founder and CEO of Flagship Pioneering. The park is a unique collaboration between the state and a private group, the Armenian Heritage Foundation, which has created the park and is tasked with maintaining it. When he used to come home from school, she did not ask him what he learned that day, but rather asked, what good questions did you ask in school today, Isadore?Later, Rabis good questions helped led him to discover nuclear magnetic resonance the foundation of todays lifesaving MRI imaging devices. [1][3][2] His grandfather survived the Armenian genocide. Miller is the founder and executive chairman of healthcare services provider Universal Health Services, which conducts testing for Covid-19 and treats patients at its network of hospitals across the U.S. Cao Xiaochun is the cofounder and director of pharmaceutical contract research outfit Hangzhou Tigermed Consulting, which supported clinical trials for CanSinos Covid-19 vaccine. Celebrating! Flagship Pioneering, the investor behind Covid-19 vaccine maker Moderna, said today that it had raised $3.4 billion for a new fund. Copyright 2021 The Armenian Mirror-Spectator. According to SEC filings, Afeyan owns at least 75% of Flagship, and the firm directly owns 4% of Flagship Ventures Fund IV but doesnt own any of Flagship Ventures Fund IV-Rx. But as Afeyan, an Armenian immigrant by way of Lebanon and Canada, turned on the charm Bancel, who was then CEO of French diagnostics maker BioMrieux, relented and agreed to come to Moderna. He thanked the organizers on behalf of Mayor Martin J. Walsh, adding, We thank you for bringing the park to us and keeping it. It was only days after Pfizer announced clinical trials showed the vaccine was 90% effective at preventing COVID-19. This remains a long game, however, as researchers work out the science and go through clinical trials. [5][7][3] He graduated from Loyola High School in Montreal in 1978. In 2000, Afeyan founded Flagship Pioneering to create and fund early-stage start-ups addressing unmet needs in healthcare and sustainability. Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and . Building a startup is always an iterative process. Executives at Moderna and other pharma companies that developed vaccines for Covid-19, including Pfizer and Novavax, sold a further $400 million in shares over the same time period, for a total of $1.9 billion. Sure, the 59-year-old founder and CEO of "venture. SheKnows. I think its not natural for him, its not comfortable.The man is doing many, many things simultaneously., Like many Armenians, Noubar Afeyans family moved from country to country, trying to find a safe haven. But Afeyan didnt care what anyone else thought. Now, back to the back story how Jews changed the world during the remarkable one hundred years, 1847-1947, according to Lebrecht. Donald Trump cannot take credit for the vaccines. The vaccine or the platform? Every one of our companies is born to aspire to what Moderna has done, he told Forbes during an interview at Flagships offices overlooking the Charles River. This gave Jews a comparative advantage in the burgeoning commercial economy, in crafts, trade, commerce, moneylending, banking, finance and medicine. Not every Moderna billionaire has been reducing their position, though: Founding investor Timothy Springer and cofounder Robert Langer, both professors at Harvard and MIT, respectively, also became billionaires thanks to their Moderna holdings but neither has sold a share since the company was founded in 2010. But there are great many other Jewish geniuses in his book, far less well-known. on track to return investors money 15-fold. His wife, Brenda, who studied at Harvard's Divinity School, recently launched a second foundation called Champions of Love. His company, Flagship Pioneering, is in the business of starting other companies using a methodological set of steps. Gregorian is the former president of Brown University as well as the NewYork Public Library. Founded in 2000, Flagship is an enterprise where entrepreneurially-minded scientists invent seemingly unreasonable solutions to challenges facing human health and sustainability. Rounding out the group of Moderna sellers is Juan Andres, the firms chief technical operations and quality officer, who sold shares worth $27.2 million. Bancel is the CEO of Cambridge, Massachusetts-based Moderna, which had its Covid-19 vaccine authorized by the U.S. Food and Drug Administration on December 18, 2020. In July, Ring raised $117 million, bringing in T. Rowe Price among other investors. He observes that Mahler used to say, Jews are like swimmers with short arms, they must invest twice as much effort to reach safe shores. Afeyan noted that he was especially delighted to have Gregorian there. Noubar Afeyan is founder, Senior Managing Partner and CEO of Flagship Ventures, a leading early stage venture capital firm. (Each year the two halves of the sculpture are pried apart and reconfigured in a new way, to symbolize leaving the past and creating a new life. By Noubar Afeyan. That is why the city has progressed. He was born to Armenian parents in Lebanon and immigrated with his family in his early teens to Canada. On the contrary, reviews of the UK and US editions by non-Jews have been very positive, some with an air of near-astonishment, indicating that previous historians had not connected the dots between the vast number of Jews who were active in the period. Noubar Afeyan, co-founder and chairman of Moderna, discussed a new COVID-19 therapeutic and booster shots during an exclusive interview on Tuesday, noting that there could be a "continuous need . Since Flagships launch, Afeyan has helped start some 70 companies. With $17 billion and a model of "parallel entrepreneurship," he can fund a lot of wild. Another pandemic-era billionaire, Uur ahin of German biotech outfit BioNTech, has also never sold a share in the company he cofounded in 2008 with his wife (and the firms chief medical officer) zlem Treci. (Baker and Walsh, as well as Middlesex County Sheriff Peter Koutoujian were honorary chairs of the banquet.). [7] He received his B.Eng. I thought I didnt have much of a downside, he says. At the time of Flagships founding two decades ago, biotech was out of favor and so-called platform companiesthat worked on a concept like mRNA rather than a specific drugwere the most unpopular. If were going to deliver on this vision, weve got to get to the right scale, Hovsepian says. Sartorius provides lab supplies for Covid-19 testing and assists vaccine manufacturers in the development process. He has written numerous scientific publications and is the inventor of over 100 patents. Ren Jinsheng is the founder and chairman of pharmaceuticals supplier Simcere Pharmaceutical Group, which increased its production of antiviral drugs arbidol and zanamivir in response to higher demand in the hopes they could help treat Covid-19. Starting one successful company is a fine achievement. It was another to make it a process, Afeyan says. [7] The company's annual revenues grew to $100 million and in 1998 was acquired by PerkinElmer/Applera and became CBO of Applera. Stanley Erck, the CEO of Novavaxwhich is aiming to secure FDA emergency authorization of its Covid-19 vaccine in the second quarter of 2021sold about $9.3 million (pretax) of Novavax shares in late September and early November. Primary Menu Sections Search By 2020, Flagship had more than doubled the pace to average of five startups a year. Over time, Afeyan set up a structure for brainstorming new companies. Tanimura is the founder of Tokyo-based online medical services provider M3, which offers its AI-powered image analysis technology to remotely diagnose Covid-19 by looking at medical images; the firm also ran clinical studies for Modernas vaccine at its facility in Raleigh, North Carolina. Xiong Jun chairs biopharma company Shanghai Junshi Biosciences, which worked with Eli Lilly to co-develop antibody treatments for Covid-19. With $17 billion and a model of parallel entrepreneurship, he can fund a lot of wild notions. Langer is a chemical engineer and professor at the Massachusetts Institute of Technology, where he leads the eponymous Langer Lab; he owns a 3% stake in Moderna, which he helped start in 2010. Stephane Bancel, Liu Fangyi and Ugur Sachin, Adam Glanzman/Bloomberg, Abdulhamid Hosbas/Anadolu Agency/Getty Images, Courtesy of Liu Fangyi. "[36] In July 2021 Afeyan met with Pashinyan in Yerevan. Deval Patrick and an official delegation from Armenia. Noubar is a member of the Corporation of MIT (the Institute's governing body) and a member of the board of overseers for the Boston Symphony Orchestra. Modernas fifth-largest individual shareholder, president Stephen Hoge, sold $65.5 million worth of Moderna stock since March 2020; Hoges 0.4% stake in Moderna is worth roughly $300 million, but he also owns about $545 million in options. transformed Judaism from a cult based on ritual sacrifices to a religion whose main norm required every Jewish man to read and study the Torah in Hebrew and to send his sons to school or synagogue to learn to do so. He added that the newcomers bring in hundreds of millions of dollars in taxes to the city and state. Gratitude, he said, is the ultimate renewable resource, infecting giver and receiver positively. The seeming courage it would take to do these things is rooted in being unrooted, he says. If I had thought about it a lot, I am very sure I would not have started a company. The work in the microbiome, in part, led to more recent work on viruses as Afeyan and his team questioned whether there are viruses in our bodies that arent pathological. The program also was a fundraiser for the maintenance of Bostons Armenian Heritage Park on the Greenway and it did not disappoint; the roughly 500 people gathered there raised $700,000. Noubar Afeyan launched 70 companies by pushing researchers to ask what if their craziest ideas were true. Dr. Avak Kahvejian (Leo Gozbekian photo), In her opening comments, Barbara Tellalian, a tireless fundraiser for the park and the wife of its designer, architect Donald Tellalian, said the park as well as the evening was dedicated to what connects us, celebrating the American immigrant experience., Next, Armenian Heritage Foundation President James Kalustian brought a congratulatory message from Gov. What lies behind that phenomenon is what prompted me to write the book. [See The Chosen Few, the Report, Septemer 9 2013].They write: The destruction of the Second Temple in 70 C.E. And its not just the vaccine discoverers: companies that mass produce the vaccines and contract research firms that help firms run clinical trials have both reaped the rewards, creating new fortunes for people like Juan Lpez-Belmonte Lpez of Spanish pharma outfit Rovi and Karin Sartorius-Herbst and Ulrike Baro of German biopharma firm Sartorius AG. He is very contrarian in all things.. Immigrant-Founded Moderna Leading The Way In Covid-19 Response, A Wave Of Insider Selling Has Completed Morgan Stanleys Moderna Shuffle, 'MIT Solve' Enables Tech Entrepreneurs To Conquer Global Social Challenges, International Students Are Founding America's Great Startups, Noubar Afeyan Has Had 38 Biotech Wins. Editors note, April 22, 2021: This story was updated with comment from Flagship Pioneering. But I fell short. "Whether or not the United States and Russia intervene to quell the violence has implications for vulnerable peoples around the world. I will go to my grave believing it is the platform., 15 Under 40: The Youngest Billionaires On The 2021 Forbes 400, Meet The 44 Newcomers Joining The Forbes 400 List Of America's Richest People. The unprecedented boom in healthcare stocks helped mint at least 40 new billionaires with ties to companies fighting Covid-19. [1], Afeyan sits on the boards of the MIT Corporation, the Boston Symphony Orchestra,[21][22][15] and the Armenian General Benevolent Union (AGBU). Lpez-Belmonte Lpez chairs Spanish pharma company Rovi, which inked a contract with Moderna in July to fill and package hundreds of millions of doses of its Covid-19 vaccine at Rovi's factory in Madrid, Spain. On Friday, November 13, Prime Minister Benjamin Netanyahu signed a deal with the giant US pharmaceutical company Pfizer to purchase millions of coronavirus vaccine doses. They said, How can anyone give you money? The vaccine was developed two days after [publication of the coronaviruss genomic] sequence. Modernas chief medical officer is Dr. Tal Zaks, an Israeli who completed his M.D. Forbes 35th Annual Worlds Billionaires List: Facts And Figures 2021, Operation Wealth Speed: What A Record Number Of New, Self-Made Billionaires Says About Capitalism, These 11 Colleges Have Produced The Most Billionaire Alumni, The Covid Billionaire Who Wants To Put Undocumented Immigrants In Americas Finest Colleges, Kim Kardashian West Is Officially A Billionaire, The Worlds Richest Healthcare Billionaires In 2021, Meet The New Billionaire Behind Kazakhstans Surprisingly Hot Brokerage, The Top Richest Women In The World In 2021. This past April, for example, Ohana Biosciences, a fertility company that focused on sperm-based treatments, shut its doors and laid off most of its staff a little over a year after emerging from stealth. The 400 wealthiest Americans saw their collective fortune increase 40% over the last year, to $4.5 . In 1999, Afeyan founded the predecessor company to Flagship Pioneering and set up shop in an office park in suburban Cambridge. Noubar, like so many immigrants who survived the Armenian Genocide and their descendants triumphed [over tragedy] and the world is a far better place for the contributions of our honoree, Kalustian said. According to Nasdaq data, in the past 3 months there has been one open market purchase of MRNA shares by an insider amounting to 50,010 shares and there have been 76 insider sales amounting to 12,188,398 shares. Moderna Therapeutics, Inc., cofounder Noubar Afeyan (Hon.'21) told graduates at BU's advanced degree ceremony on Sunday morning that he hopes their experience with COVID-19 will drive them to find innovative answers to future pandemics and other world problems. But that is not the reason I wrote Genius and Anxiety. Noubar Afeyan. While Modernas chairman may be behind the biggest sales, the pharmaceutical executive who personally sold the most shares is Moderna CEO Stphane Bancel. The underlying cause of most autoimmune diseases is related to T-cell misbehavior, Cox explains. Afeyan added his praise to the organizations that were recognized for their work and especially the timing of the recognition at a time they are very much needed., I congratulate them and thank them for being here, he said. He did his undergraduate work at McGill University and completed his PhD in biochemical engineering in MIT. Have you wondered how to push the limits of your imagination in your research to drive significant and impactful change? Flagship Pioneering, a VC fund run and majority owned by Moderna chairman and cofounder Noubar Afeyan, sold $1.4 billion of shares in late February and late March. ahin is the CEO and cofounder of BioNTech, which he started alongside his wife and chief medical officer zlem Treci. As the companies grow, Flagship brings in outside investors, typically raising $100 million or more, with a view toward ultimately going public. Here's How His Formula Challenges Silicon Valley Dogma, In His Spare Time, Immigrant Noubar Afeyan Has Started 38 Companies In America, Do Not Sell or Share My Personal Information, Limit the Use of My Sensitive Personal Information. It is also building out a new division focused on preemptive medicine, a more personalized, predictive type of preventive health care, as well as health security to better prepare for future threats from infectious diseases. Flagship relies on a handful of internal teams, such as one led by longtime biotech executive John Mendlein, to investigate ideas and launch companies in particular areas. The dotcoms were infatuating the markets. [3][1] By 2020 Afeyan had co-founded and developed 41 start-ups. Afeyan has helped start more than 70 public and private healthcare and life sciences companies over the course of his career. Bancel knew he needed to reach out to Moderna cofounder Noubar Afeyan, the serial biotech entrepreneur who runs Flagship Pioneering in Cambridge and chairs Moderna's board of directors. A man of many faces. Was it perhaps because of your book about the Jewish composer Gustav Mahler? . Later reports raised its effectiveness to 95%. BOSTON Immigrants and their unique and vital contributions to the success of the US economy since the nations founding were the dominant themes of a program paying tribute to Dr. Noubar Afeyan, biotech innovator and philanthropist, on Wednesday, September 18, at the InterContinental Hotel. Armenian American entrepreneur, inventor and philanthropist Noubar Afeyan has been listed 212th on the Forbes list of 400 richest Americans. The writer heads the Zvi Griliches Research Data Center at S. Neaman Institute, Technion and blogs at www.timnovate.wordpress.com, Hebrew edition: Kinneret, Zmora, Dvir: Modi-in, 2020, 511 pages, Sign up for The Jerusalem Post Premium Plus for just $5, Upgrade your reading experience with an ad-free environment and exclusive content. What keeps you from innovating is being comfortable. Part of it is an innate comfort with discomfort and with not thinking that everything has to be just so.. Yuan Liping received a 24% stake in vaccine maker Shenzhen Kangtai Biological Products after divorcing the firm's chairman Du Weimin in 2020. ( 25, 1962 [1], , ), , Flagship Ventures [2] . Not everything goes smoothly, of course. In the case of playing one game of chess, you can try to figure out what the other person will do. life sciences innovation firm Flagship Pioneering. Why Are Moderna Insiders Selling So Many Shares? [16][17], Afeyan started his first biotechnology company in 1987, just a few days before Black Monday, and founded or co-founded five more companies within ten years. By incubating its own ideas and doing all the seed and early stage venture funding itself, Flagship typically still owns 50% or so at the time of its startups IPOs, according to Afeyan. Why wouldnt you think you can actually change the world in the particular area you are working on?. Noubar Afeyan. Flagship Pioneering, a VC fund run and majority owned by Moderna chairman and cofounder Noubar Afeyan, sold $1.4 billion of shares in late February and late March. Charlie Baker. [4], Afeyan was born to Armenian parents in Beirut, Lebanon in 1962. The answer matters because in gene therapy, treatments are delivered by viruses and those viruses have downsides. He also leads the firm's VentureLabs unit that invents and launches transformative startups. During the Armenian genocide of 1915-16, in which as many as 1.2 million Armenian Christians living in the Ottoman Empire were killed, Afeyans paternal grandfather and great uncle were taken away twice, he says. And what if, he asked a decade ago, messenger RNA (mRNA) could be the basis of therapeutics? Noubar Afeyan, chairman and co-founder of Moderna, joins Fareed to talk about the new Omicron coronavirus variant. I think of it as chess. 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